Tobacco Consumption During Pregnancy and its Association with Psychosocial Child Development


Emory University, USA
, 3rd rev. ed.

PDF version

Introduction

Self-report studies reveal that 7 to 25% of women of childbearing age in the United States endorse current smoking, including the use of electronic nicotine delivery systems (ENDS), which have recently increased in popularity.1-2 Meta-analyses suggest that maternal tobacco consumption during pregnancy is associated with negative child behavioural and mental health outcomes, including attention deficit hyperactivity disorder, conduct problems, mood disorders, and schizophrenia.3-6 Given the fact that almost half of the women who consume tobacco prior to pregnancy continue to do so throughout pregnancy,7 these tobacco–behavioural linkages may have far-reaching implications for development and mental health in children.

Subject

Studies have linked maternal tobacco consumption during pregnancy to a number of adverse medical outcomes. Meta-analytic reviews report significant associations between maternal tobacco use in pregnancy and negative child health outcomes including low birthweight, sudden infant death syndrome, asthma, and obesity.8 As noted above, the deleterious effects of maternal prenatal smoking on child development appear to extend to the psychosocial realm as well. This report reviews the evidence for the connection between maternal tobacco consumption and psychosocial child development and discusses relevant implications for interventions and public health policy.

Problems

The study of maternal tobacco consumption and its effect on child behavioural or psychosocial outcomes is fraught with methodological problems. The most serious methodological concern is the difficulty in establishing a causal connection due to the potential role of confounds in this process.9 Research in this area is quasi-experimental. For obvious ethical reasons, women are not randomly assigned to smoke or not to smoke during pregnancy. However, the factors identified with women who do smoke typically differ from those of women who do not in a number of different areas, including genetic and cultural background, childhood history of antisocial behaviour, socioeconomic status, mental health, personality traits, parenting styles, and exposure to stressful life events. These factors, in turn, are associated with greater risk for problematic child psychosocial development. However, no single study has been able to control for all of these potential confounds. Another methodological concern is the common use of retrospective rather than prospective reports of maternal smoking. The finding that maternal self-reports of smoking during pregnancy are highly correlated with direct biochemical measures10 alleviates major concerns about the exclusive use of self-reports of maternal smoking in this research area. However, there remains a lingering concern regarding the capacity of self-report to detect exposure from various sources (i.e., second-hand exposures). Recent findings indicate that self-reported data should be supplemented with biological measurements of exposure. These data find that integrative assessments, that combine multiple measures of use, better reflect overall exposure and are most proficient in identifying the behavioural consequences associated with substance use.11

Research Context

Maternal prenatal smoking and its relationship to child psychosocial outcomes has been examined in both cross-sectional and longitudinal studies, and in both clinical and community samples. Animal studies have examined the effect of nicotine exposure on behavioural outcomes and brain functioning and neurobiological deficits have been suggested as a likely mediator for negative behavioural outcomes.12 Human studies support this contention, noting associations between maternal prenatal smoking and reductions in frontal lobe volumes in infants,13 decreased cortical thickness in children,14 and a thinning of the cerebral and, potentially, orbitofrontal cortices in adolescents.15 Nevertheless, there remains disagreement in the field concerning the relative importance of the direct effects of prenatal tobacco smoking, its associated familial background factors, and potentially moderating environmental or genetic vulnerabilities in the prediction of negative child behavioural outcomes.

Key Research Questions

The key research questions in this area are as follows:

  • Is maternal tobacco consumption during pregnancy associated with deleterious behavioural outcomes in youth? And, if so:
  • Can potential methodological confounds account for this association? And, if not:
  • Are these risks specific to particular behavioural outcomes?
  • Are these risks moderated by other factors including genetics, the biological sex of the child, co-exposures, or the environmental context of development?

Recent Research Results

Maternal prenatal smoking has been associated with increased risk for Attention Deficit Hyperactivity Disorder, oppositional behaviour, aggression, conduct disorder, problematic language and cognitive development, and substance misuse outcomes in youth.16-21  A majority of studies suggest that statistical control for a range of potential confounds, including parental criminality, maternal mental health, parenting behaviour, socioeconomic status, prenatal exposure to drugs and alcohol, and other perinatal complications, does not change the general pattern of results. However, a few studies have found that the maternal prenatal smoking child outcome relationship is no longer significant when maternal background characteristics (e.g., childhood history of conduct disorder) and mother-child relationship qualities are taken into account.22-24 Although evidence from twin studies suggests that the relationship between maternal smoking during pregnancy and child behaviour problems cannot be entirely accounted for by genetic influences,22,25 recent studies using innovative design strategies have suggested that genetic or familial background factors may be essential components of the prenatal smoking and child externalizing behaviour association.26,27

The noted maternal prenatal smoking child behaviour outcome association appears stronger for externalizing or acting out behaviours; results from studies examining the associations between maternal prenatal smoking and child internalizing problems have been mixed.9,28-30

In addition, offspring biological sex appears to moderate the effects of maternal prenatal smoking on child psychosocial outcomes. Specifically, results are stronger for males in terms of the outcomes of conduct disorder,  and stronger for females in terms of the outcome of substance misuse.20,31 Family and socioeconomic context has been shown to moderate the effect of maternal prenatal smoking on child outcomes.16,32,33 Gene by environment interaction studies also suggest that several distinct genetic polymorphisms, (including one that effects the metabolism of smoking-related carcinogens), may moderate the association between maternal prenatal smoking and child externalizing behaviour.34-36 Furthermore, maternal genetic profiles have been associated with the reduction or spontaneous quitting of smoking during pregnancy.37 Epigenetic processes have also been identified as potential mechanisms through which maternal prenatal smoking may confer risk for vulnerabilities in child development. For instance, maternal smoking can affect embryonic DNA methylation which, in turn, can impact gene expression, phenotyping, and ultimately offspring behaviour later in life.38 Moreover, DNA methylation has been found to mediate outcomes such as offspring neurodevelopment, memory, cognition, and attention, all of which can influence psychosocial development.39-42 Further study of maternal psychosocial and genetic characteristics associated with cessation of smoking during pregnancy is needed to more effectively design intervention programs focused on pregnant women.

Conclusions

There are several possible mechanisms or explanations for the noted relationship between maternal prenatal smoking and behavioural problems in offspring. One possible explanation is that prenatal exposure to this teratogen increases the risk for child externalizing problems, but only in genetically or otherwise environmentally vulnerable individuals.  Alternatively, maternal prenatal smoking may serve as a marker for other environmental effects that increase the risk of externalizing problems in children. For example, maternal prenatal smoking may be an indicator of a passive, neglectful parenting style. It may not reflect abuse or overt parental hostility but rather a subtle disruption in the parent-child relationship that is difficult to measure via questionnaires or short-term observations, but that nevertheless increases the risk for externalizing problems in children. An additional possibility is that maternal cigarette smoking may set off a chain of transactional biological and environmental factors that act together to increase risk for deleterious child development. Our understanding of this transactional process is rudimentary at this time.

Implications

Not all children whose mothers smoked during pregnancy will manifest deficits in behaviour or developmental outcomes. Future studies aimed at assessing the potentially moderating risk and protective factors in this process would be useful in designing effective prevention and intervention programs. A public health approach calls for prevention and intervention strategies designed to reduce the known risk factors for these deleterious psychosocial outcomes in children. Maternal prenatal smoking is a relatively modifiable perinatal risk factor. Smoking cessation programs for pregnant women,43 which may include novel mobile phone-based interventions,44 financial incentives,45 short-term and long-term nicotine replacement therapies,46,47 and even low-intensity counselling interventions by general practitioners,48 have been found to reduce or eliminate maternal smoking during pregnancy. An examination of the behavioural profiles of the children whose mothers successfully completed such programs would help provide important experimental evidence concerning the potentially causal role of maternal prenatal smoking on child behaviour problems.

References

  1. March of Dimes: PeriStats Database. 2019. https://www.marchofdimes.org/peristats/. Accessed November 23, 2023.
  2. Tehrani H, Rajabi A, Ghelichi-Ghojogh M, Nejatian M, Jafari A. The prevalence of electronic cigarettes vaping globally: a systematic review and meta-analysis. Archives of Public Health 2022;80(1):1-15.
  3. Duko B, Ayano G, Pereira G, Betts K, Alati R. Prenatal tobacco use and the risk of mood disorders in offspring: a systematic review and meta-analysis. Social Psychiatry and Psychiatric Epidemiology 2020;55:1549-1562.
  4. He Y, Chen J, Zhu LH, Hua LL, Ke FF. Maternal smoking during pregnancy and ADHD: results from a systematic review and meta-analysis of prospective cohort studies. Journal of Attention Disorders 2020;24(12):1637-1647.
  5. Hunter A, Murray R, Asher L, Leonardi-Bee J. The effects of tobacco smoking, and prenatal tobacco smoke exposure, on risk of schizophrenia: a systematic review and meta-analysis. Nicotine and Tobacco Research 2020;22(1):3-10.
  6. Ruisch IH, Dietrich A, Glennon JC, Buitelaar JK, Hoekstra PJ. Maternal substance use during pregnancy and offspring conduct problems: A meta-analysis. Neuroscience & Biobehavioral Reviews 2018;84:325-336.
  7. Xie S, Monteiro K, Gjelsvik A. The association between adverse birth outcomes and smoking cessation during pregnancy across the United States—43 States and New York City, 2012–2017. Archives of Gynecology and Obstetrics 2023;308(4):1207-1215.
  8. Avşar TS, McLeod H, Jackson L. Health outcomes of smoking during pregnancy and the postpartum period: an umbrella review. BMC pregnancy and childbirth 2021;21:1-9.
  9. Brion MJ, Victora C, Matijasevich A, Horta B, Anselmi L, Steer C, Menezes AM, Lawlor DA, Davey Smith G. Maternal smoking and child psychological problems: Disentangling causal and noncausal effects. Pediatrics 2010;126(1):e57-65.
  10. McDonald SD, Perkins SL, Walker MC. Correlation between self-reported smoking status and serum cotinine during pregnancy. Addictive Behaviors 2005;30(4):853-857.
  11. Shisler S, Eiden RD, Molnar DS, Schuetze P, Huestis M, Homish G. Smoking in pregnancy and fetal growth: the case for more intensive assessment. Nicotine & Tobacco Research 2017;19(5):525-531.
  12. Fung YK. Postnatal behavioral effects of maternal nicotine exposure in rats. Journal of Pharmacy and Pharmacology 1988;40(12):870-872.
  13. Ekblad M, Korkeila J, Parkkola R, Lapinleimu H, Haataja L, Lehtonen L, PIPARI Study Group. Maternal smoking during pregnancy and regional brain volumes in preterm infants. Journal of Pediatrics 2010;156(2):185-190.
  14. El Marroun H, Schmidt MN, Franken IH, Jaddoe VW, Hofman A, van der Lugt A, Verhulst FC, Tiemeier H, White T. Prenatal tobacco exposure and brain morphology: a prospective study in young children. Neuropsychopharmacology 2014;39(4):792-800.
  15. Toro R, Leonard G, Lerner JV, Lerner RM, Perron M, Pike GB, Richer L, Veillette S, Pausova Z, Paus T.  Prenatal exposure to maternal cigarette smoking and the adolescent cerebral cortex. Neuropsychopharmacology 2008;33(5):1019-1027.
  16. Wakschlag LS, Henry DB, Blair RJ, Dukic V, Burns J, Pickett KE.  Unpacking the association: Individual differences in the relation of prenatal exposure to cigarettes and disruptive behavior phenotypes. Neurotoxicology and Teratology 2011;33(1):145-54.
  17. Hutchinson J, Pickett KE, Green J, Wakschlag LS. Smoking in pregnancy and disruptive behaviour in 3-year-old boys and girls: an analysis of the UK Millennium Cohort Study. Journal of Epidemiological and Community Health 2010;64(1):82-88.
  18. Huang L, Wang Y, Zhang L, Zheng Z, Zhu T, Qu Y, Mu D. Maternal smoking and attention-deficit/hyperactivity disorder in offspring: A meta-analysis. Pediatrics 2018;141(1):e20172465.
  19. Day NL, Richardson GA, Goldschmidt L, Cornelius MD. Effects of prenatal tobacco exposure on preschoolers' behavior. Journal of Developmental and Behavioral Pediatrics 2000;21(3):180-188.
  20. Weissman MM, Warner V, Wickramaratne PJ, Kandel DB. Maternal smoking during pregnancy and psychopathology in offspring followed to adulthood. Journal of the American Academy of Child and Adolescent Psychiatry 1999;38(7):892-899.
  21. Hernández-Martínez C, Voltas Moreso N, Ribot Serra B, Arija Val V, Escribano Macías J, Canals Sans J. Effects of prenatal nicotine exposure on infant language development: A cohort follow up study. Maternal and Child Health Journal 2017;21(4):734-744.
  22. Maughan B, Taylor A, Caspi A, Moffitt TE. Prenatal smoking and early childhood conduct problems: Testing genetic and environmental explanations of the association. Archives of General Psychiatry 2004;61(8):836-843.
  23. Roza SJ, Verhulst FC, Jaddoe VW, Steegers EA, Mackenbach JP, Hofman A, Tiemeier H.  Maternal smoking during pregnancy and child behaviour problems: the Generation R Study. International Journal of Epidemiology 2009;38(3):680-689.
  24. Lavigne JV, Hopkins J, Gouze KR, Bryant FB, Lebailly SA, Binns HJ, Lavigne PM. Is smoking during pregnancy a risk factor for psychopathology in young children? A methodological caveat and report on preschoolers. Journal of Pediatric Psychology 2011;36(1):10-24.
  25. Thapar A, Fowler T, Rice F, Scourfield J, van den Bree M, Thomas H, Harold G, Hay D. Maternal smoking during pregnancy and attention deficit hyperactivity disorder symptoms in offspring. American Journal of Psychiatry 2003;160(11):1985-1989.
  26. D'Onofrio BM, Van Hulle CA, Waldman ID, Rodgers JL, Harden KP, Rathouz PJ, Lahey BB. Smoking during pregnancy and offspring externalizing problems: An exploration of genetic and environmental confounds. Developmental Psychopathology 2008;20(1):139-164.
  27. Thapar A, Rice F, Hay D, Boivin J, Langley K, van den Bree M, Rutter M, Harold G. Prenatal smoking might not cause attention-deficit/hyperactivity disorder: Evidence from a novel design. Biological Psychiatry 2009;66(8):722-727.
  28. Eiden RD, Zhao J, Casey M, Shisler S, Schuetze P, Colder CR. Pre- and postnatal tobacco and cannabis exposure and child behavior problems: Bidirectional associations, joint effects, and sex differences. Drug and Alcohol Dependence 2018;185:82-92.
  29. Cornelius M, Goldschmidt L, DeGenna N, Day NL. Smoking during teenage pregnancies: effects on behavioral problems in offspring. Nicotine & Tobacco Research 2007;9(7):739-750.
  30. Carter S, Paterson J, Gao W, Iusitini L. Maternal smoking during pregnancy and behaviour problems in a birth cohort of 2-year-old Pacific children in New Zealand. Early Human Development 2008;84(1):59-66.
  31. Fergusson DM, Woodward LJ, Horwood LJ. Maternal smoking during pregnancy and psychiatric adjustment in late adolescence. Archives of General Psychiatry 1998;55(8):721-727.
  32. Wakschlag LS, Hans SL. Maternal smoking during pregnancy and conduct problems in high-risk youth: A developmental framework. Development and Psychopathology 2002;14(2):351-369.
  33. Huijbregts Huijbregts SC, Séguin JR, Zoccolillo M, Boivin M, Tremblay RE. Maternal prenatal smoking, parental antisocial behavior, and early childhood physical aggression. Development and Psychopathology 2008;20:437-453.
  34. Neuman RJ, Lobos E, Reich W, Henderson CA, Sun LW, Todd RD. Prenatal smoking exposure and dopaminergic genotypes interact to cause a severe ADHD subtype. Biological Psychiatry 2007;61(12):1320-1328.
  35. Hsieh CJ, Jeng SF, Su YN, Liao HF, Hsieh WS, Wu KY, Chen PC. CYP1A1 modifies the effect of maternal exposure to environmental tobacco smoke on child behavior. Nicotine and Tobacco Research 2010;12(11):1108-1117.
  36. Wakschlag LS, Kistner EO, Pine DS, Biesecker G, Pickett KE, Skol AD, Dukic V, Blair RJ, Leventhal BL, Cox NJ, Burns JL, Kasza KE, Wright RJ, Cook EH Jr. Interaction of prenatal exposure to cigarettes and MAOA genotype in pathways to youth antisocial behavior. Molecular Psychiatry 2010;15(9):928-937.
  37. Chen X, Woodcroft KJ. Polymorphisms in metabolic genes CYP1A1 and GSTM1 and changes in maternal smoking during pregnancy. Nicotine and Tobacco Research 2009;11(3):225-33.
  38. Buck JM, Yu L, Knopik VS, Stitzel JA. DNA methylome perturbations: an epigenetic basis for the emergingly heritable neurodevelopmental abnormalities associated with maternal smoking and maternal nicotine exposure. Biology of Reproduction 2021;105(3):644-66.
  39. Paquette AG, Lester BM, Lesseur C, Armstrong DA, Guerin DJ, Appleton AA, Marsit CJ. Placental epigenetic patterning of glucocorticoid response genes is associated with infant neurodevelopment. Epigenomics 2015;7:767-779.
  40. Morris MJ, Adachi M, Na ES, Monteggia LM. Selective role for DNMT3a in learning and memory. Neurobiology of Learning and Memory 2014;115:30-37.
  41. Nguyen T, Li GE, Chen H, Cranfield CG, McGrath KC, Gorrie CA. Maternal e-cigarette exposure results in cognitive and epigenetic alterations in offspring in a mouse model. Chemichal Research in Toxicology 2018;31(7):601-611
  42. Jung Y, Hsieh LS, Lee AM, Zhou Z, Coman D, Heath CJ, Hyder F, Mineur YS, Yuan Q, Goldman D, Bordey A, Picciotto MR. An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior. Nature Neuroscience 2016;19(7):905-914.
  43. Ford RPK, Cowan SF, Schluter PJ, Richardson AK, Wells JE. Smoke Change for changing smoking in pregnancy. New Zealand Medical Journal 2001;114(1128):107-110.
  44. Kurti AN, Nighbor TD, Tang K, Bolívar HA, Evemy CG, Skelly J, Higgins ST. Effect of smartphone-based financial incentives on peripartum smoking among pregnant individuals: A randomized clinical trial. JAMA Network Open 2022;5(5):e2211889.
  45. Ierfino D, Mantzari E, Hirst J, Jones T, Aveyard P, Marteau TM. Financial incentives for smoking cessation in pregnancy: A single‐arm intervention study assessing cessation and gaming. Addiction 2015;110(4):680-688.
  46. Oncken C, Dornelas E, Greene J, Sankey H, Glasmann A, Feinn R, Kranzler HR. Nicotine gum for pregnant smokers: a randomized controlled trial. Obstetrics and Gynecology 2008;112(4):859-867.
  47. El-Mohandes AA, Windsor R, Tan S, Perry DC, Gantz MG, Kiely M. A randomized clinical trial of trans-dermal nicotine replacement in pregnant African-American smokers. Maternal and Child Health Journal 2013;17(5):897-906.
  48. Melvin CL, Dolan-Mullen P, Windsor RA, Whiteside HP, Goldenberg RL. Recommended cessation counselling for pregnant women who smoke: a review of the evidence. Tobacco Control 2000;9(suppl. 3):80-84.

How to cite this article:

Brennan P, Stanfield J. Tobacco Consumption During Pregnancy and its Association with Psychosocial Child Development. In: Tremblay RE, Boivin M, Peters RDeV, eds. Wakschlag LS, topic ed. Encyclopedia on Early Childhood Development [online]. https://www.child-encyclopedia.com/tobacco-and-pregnancy/according-experts/tobacco-consumption-during-pregnancy-and-its-association. Updated: November 2023. Accessed February 27, 2024.

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